Initially, Spike loves unconditionally Drusilla, until the day she dumps him for a Chaos Demon. To heal Spike's heart, the recent turned vampire Harmony appears, but the two of them don't stay together for long, because a new love is born in Spike's heart — Buffy, The Vampire Slayer. With Anya, the vampire has sex once, after both demons were hurt by their lovers.

Spike & Drusilla

Spike is destroyed because his beloved [Drusilla] walked out on him (Lovers Walk), after they being together over 100 years; he returns to Sunnydale, to the old burned-out factory where he and Dru used to live, and there he finds Drusilla's doll collection. As they remind him of her, he ends up getting very angry, and smashes one of them with a candlestick.

Later, Spike kidnaps Willow in order for her to make a love spell; while prisoner of the vampire, poor Willow listens to Spike's lamentations — not that she had another alternative. He tells the witch that Dru, while they were in Brazil, cheated on him with a disgusting Chaos Demon, "They're all slime and antlers."

Worst of all, Dru said they could still be friends!

God, I'm so unhappy! I mean, friends! How could she be so cruel?

And he goes on talking about his miserable love life to Buffy's mom, Joyce, while she fixes for him a cup of hot chocolate (the two of them always got along well); once more, he tells the tale about Dru and the Chaos Demon, and their fight over it. Although devastated, Spike doesn't forget to ask Joyce for "those little marshmallows"...

Spike& Harmony

With vampire [Harmony], a very bad relationship; Spike wasn't very nice to her, but let's be honest here, Harm was VERY annoying... They were together when Spike discovered himself in love with the Slayer, and when he had sex with Harm, he always was thinking of Buffy.

Sometimes, Spike used to ask Harm to wear a Buffy's blue sueter (which he had stolen) and make an impression of the Slayer. Bad, bad boy.

But it didn't take long for Spike to dump Harmony for good.

In 2003, Spike meets Harmony again; he has just died and is incorporeal, and she is Angel's secretary at Wolfram & Hart. The poor female vampire thinks Spike is still her boyfriend, and gets very shocked when she learns that he and Buffy had been together in the past few months. However, she ends up getting lucky: the first thing Spike does after being turned corporeal again is take Harmony to a room and have sex with her (Destiny).

Spike & Buffy

After several fights and forced alliances with Buffy, Spike ends up madly in love with the Slayer — and this love is revealed to him in a passionate dream (Out of My Mind): Buffy stops by his crypt, she is mad and has a stake in her hands. Spike grabs and kisses her; she kisses back, stops, and resumes the kissing. Spike wakes up.

Afterwards, he starts stalking her, doing things like entering her bedroom to smell her clothes (and he steals some pieces) or standing in front of her house for hours just to take a glance of his beloved.

In one of these watching nights, Spike sees Buffy's boyfriend [Riley] sneaking out from the house to go to a nasty place to be bitten by vampire trulls. He rushes to tell Buffy the news, hoping she will be grateful and reward him, what, obviously, doesn't happen. Afterwards, Spike is beside himself with worry and rehearses his apologies to her in front of a mannequin (Triangle) with blonde wig as "Buffy".

Riley, furious at Spike, goes to his crypt and stakes him — with a plastic stake (Into the Woods). They end up drinking together and having a conversation about Buffy, the woman they love, but aren't loved by.

Buffy and Riley split up and when Spike finally has the nerve to tell Buffy how he feels about her (Crush), she freaks out. He says he will give up evil for love, she says he is (with the chip) like a serial killer in prison.

But Spike meant it; being through a lot of changes (because of the chip and out of his love for Buffy), he stops being the cruel vampire he used to be and starts behaving like a common mortal infatuated with a girl, trying to win her love.

One day, under the evil influence of his ex-lover Drusilla, he kidnaps Buffy and chains her in his crypt, to force the Slayer listen to his "I love you."

While he isn't able to convince Buffy of his true love, Spike looks for Warren and orders a robot with Buffy features — the [BuffyBot]—and with it he has a lot of fun, until the Scoobies find out and take the toy from him...

And because of this love, Spike is constantly hurt by Buffy, not only physically, but also by the words the Slayer says to him, like in the day he told her how he became a vampire, and ended up listening from Buffy he was beneath her (Fool For Love).

Or when he sees Buffy talking cheerfully with [Ben], at The Bronze, right after having been rude with him.

Spike finally gets part of what he wants after Buffy returns from the dead — the Slayer is confused by having been torn out of Heaven and the only person she feels comfortable to talk to is the vampire. They start a realationship, but while Spike wants Buffy's love, she only wants sex from him.

See [Spuffy]

Spike& Anya

Spike and [Anya] were together just once (Entropy) and it ended very bad; Xander and Buffy caught the "whole beautiful show" through the cameras the [Troika] had placed at the [Magic Box]. Xander tried to kill Spike afterwards, and Buffy seemed very hurt by what she saw.

Later, [Dawn] went to pike crypt's to tell him he had hurt Buffy by sleeping with Anya, and asks him if he loved Buffy; Spike said nothing. The answer was obvious.

Spike speaks up about Buffy's love life and ex-boyfriends:
About Angel (said by the BuffyBot):

Willow: OK, yeah, you've been with a vampire before, but... Angel has a soul...
BuffyBot: Angel's lame. His hair goes straight up and he's bloody stupid.

About Buffy having believed in Parker's sad history about his late father and slept with him:

Spike: So, you let [Parker] take a poke, eh? Didn't seem like you know each other that well. What did it take to pry apart the Slayer's dimpled knees?
Buffy: You're a pig Spike.
Spike: Did he play the sensitive lad and get you to seduce him? That's a good trick if the girls thick enough to buy it. I wonder what went wrong. Were you too strong? Did you bruise the boy? Come to think of it seems like someone told me that. Who was it? Oh, yeah. Angel.

About Riley — who is much taller and bigger than him:

Buffy: Riley is sick, it's a Initiative thing, and he's missing.
Spike: Oh, dear, is the enormous hall monitor* sick? Tell me, is he gonna die?

Buffy punches Spike in the face:

Buffy: He is not the only person that can die.

*enormous hall monitor = Riley

Buffy finds Spike in front of her house and asks what the hell he is doing there:

Spike: You know, I'm just passing through. Satisfied? You know, I really hope so because God knows you need some satisfaction in life besides shagging Captain Cardboard* and I never really liked you anyway and... and you have stupid hair.

*Captain Cardboard = Riley

Spike telling Riley what Buffy likes:

Spike: ...What do you got, a piercing glance? Face it, white bread. Buffy's got a type, and you're not it. She likes us dangerous, rough, occasionally bumpy in the forehead region. Not that she doesn't like you... but sorry Charlie, you're just not dark enough.

Spike meets Buffy in the Spring break party:

Spike: Small world. Oh dear, if looks could stake. Are you having fun, pet? Trolling for your next ex?

Buffy looks at him as if she wanted to kill him

Spike: You think I was gonna leave town? Free country. Free party. You want me to leave you can put your hands on my hot tight little body and make me.

About Buffy's love life:

Spike: Got to hand it to you Goldilocks — you do have bleeding tragic taste in men. I've got a cousin married to a regurgitating demon that's got better instincts than you.

Buffy is having trouble fighting a vampire, and Spike comes to the rescue:

Buffy: I didn't need you. I never need you, Spike.
Spike: Oh, I get it. You just don't like who did the rescuin', that's all. Wishin' I was your boyfriend what's-his-face. Oh wait, he's run off.
Buffy: You know what? I don't need a boyfriend, to rescue me or for any other reason.
Spike: Don't need or can't keep? You keep making notches in the headboard but eventually they get up out of the bed and run off, don't they?
Buffy: You're disgusting.
Spike: Oh, rough talk. Maybe that's your problem, maybe you push 'em away. Or is it the other? Maybe you cling too much. Or maybe... your beauty's fading. The stress of slaying, aging you prematurely. Things not as high, not as firm.
Buffy: The more I get to know you, the more I wish I didn't.
Spike: Or maybe you just don't hold their interest.

About Richard, who was invited by Xander and Anya to Buffy's Birthday party:

Spike: Besides, Richie, you can't skip breakfast. Growing boy like you. Me, I used to love breakfast. In the old days, I probably would have eaten by now.

The final word:

Spike: See, the poor little twinkie can't keep a man. Gets her all down. Few more disappointments and she'll be crying on my shoulder, mark my words!

Screen caps provided by [Screencappiness]